Cells and Drugs
Cardiac function is governed by physiological mechanisms acting on length scales ranging from the subcellular level to the overall heart anatomy. Alterations to these mechanisms from normal physiological behaviour, can lead to the development of pathological conditions including heart failure. Computational modeling provides a framework for integrating experimental and clinical measurements, and serves as a “virtual laboratory” for investigating the interdependence of the different mechanisms contributing to heart disease. Through collaborations with clinical and pharmaceutical partners, we seek to improve our understanding of the mechanisms underlying heart failure. We model the impact of chemotherapeutic drugs on the molecular-level behaviour of cardiac muscle to investigate their repercussion on ATP production in mitochondria and on muscle contraction at the whole-heart level.